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Clinical Evidence

Diabetic Dry
& Itchy Skin

Clinical Study Overview

XTRIMOIST-DM Moisturizing Lotion was clinically evaluated in adults with diabetes
experiencing itchy dry skin.

Topical steroid + XTRIMOIST-DM Moisturizing Lotion

Study Duration

45 days

Study Design

Single-group, monocentric clinical study

Key Clinical Findings

Significant Improvement in Skin Hydration

Clinical instrumentation demonstrated a significant increase in skin hydration levels following regular use of XTRIMOIST-DM Moisturizing Lotion.

Clinical Results:

  • 43.7% increase in skin hydration within 5 minutes
  • 77.5% increase in skin hydration within 1 hour
  • 42.2% increase in skin hydration after 45 days

Skin hydration was measured using MoistureMeter SC, a scientific instrument used to evaluate skin moisture levels.

Improved Skin
Barrier Function

XTRIMOIST-DM demonstrated significant reduction in Trans Epidermal Water Loss (TEWL), indicating stronger skin barrier protection and improved moisture retention.

Clinical Results:

  • 15.7% reduction in TEWL within 1 hour
  • 27.9% reduction in TEWL after 45 days

TEWL measurements were assessed using VapoMeter, a clinically established instrument for evaluating moisture loss from skin.

Clinically Proven Itch
Relief

Participants experienced significant improvement in itching associated with psoriasis.

Clinical Results:

  • 100% reduction in itching within 1 hour
  • 82.9% reduction in itching after 45 days

Participants also reported noticeable relief from skin discomfort and irritation.

Participant Satisfaction After 45 days of use:

Agreed their skin
felt hydrated
0 %
Agreed their skin became
soft and smooth
0 %
Agreed itching
had reduced
0 %
Liked the
product overall
0 %

Safety & Tolerance

XTRIMOIST-DM Moisturizing Lotion was found to be
well tolerated throughout the study duration.

Clinical Safety Findings:

  • No adverse events reported
  • No irritation, burning, tingling, or prickling sensations observed
  • No clinically observed skin intolerance reactions

Quality of Life Improvement

  • Daily skin comfort 
  • Emotional well-being related to itching 
  • Appearance of skin affected by scratching 
  • Ability to work and enjoy daily activities comfortably 

Clinical assessments demonstrated significant improvements in participants’ daily comfort and quality of life.

After 45 days:

  • 25.8% of participants reported being “never bothered” by itching that affected their work or enjoyment of life.
  • 22.6% of participants reported being “never bothered” by the emotional impact of itching.

Conclusion

  • 42.2% increase in skin hydration in 5 min
  • 27.9% reduction in TEWL within 1 hour
  • 82.9% Moisture retention
  • 100% reduction in itching within 1 hour
  • Improve in skin softness and smoothness
  • Overall skin comfort and quality of life

Clinical evaluation demonstrated that XTRIMOIST-DM Moisturizing Lotion significantly improved multiple skin health parameters. Additionally, the product was well tolerated throughout the 45-day study period.

At Xtrimoist®, we go beyond surface hydration with barrier-focused skincare engineered to restore, strengthen, and protect sensitive and compromised skin from modern environmental stressors.

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