UREA

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INGREDIENT

Urea

Keratolytic & Hydration Active (NMF Component)

What is Urea?

Urea is a naturally occurring component of the skin’s Natural Moisturizing Factor (NMF), widely used in dermatological skincare for its dual keratolytic and hydrating properties. It plays a key role in maintaining skin hydration by attracting and retaining moisture, while also helping to gently exfoliate the stratum corneum. Urea is commonly used in formulations designed for dry, rough, or hyperkeratotic skin conditions, including psoriatic-type scaling and xerosis.

What Does It Do For The Skin?

04

Exhibits keratolytic
activity

At higher concentrations, urea helps break down keratin and promote the removal of dead skin cells, supporting gentle exfoliation.

05

Improves hyperkeratotic
conditions

Helps improve the appearance of thickened, rough, and scaly skin while enhancing overall skin texture and smoothness.

06

Enhances penetration of
other actives

Its exfoliating action helps improve the absorption and effectiveness of other topical ingredients.

01

Acts as a Natural Moisturizing
Factor (NMF) component

Urea is a key constituent of the skin’s NMF, helping attract and bind water to maintain optimal skin hydration.

02

Provides effective
hydration

Urea improves water retention in the skin, enhancing softness, elasticity, and overall skin smoothness.

03

Reduces transepidermal water
loss (TEWL)

By supporting skin barrier function, urea helps minimize moisture loss and promote long-lasting hydration.

Safety & Tolerability

Urea is widely used in cosmetic and dermatological formulations and is considered safe and well tolerated when used within recommended concentrations. It is suitable for dry and sensitive skin, although higher concentrations should be used appropriately in targeted formulations.

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References

1. Lodén M. The clinical benefit of moisturizers. Journal of the European Academy of Dermatology and Venereology. 2003;17(4):389–394.

2. Fluhr JW et al. Skin hydration and barrier function. British Journal of Dermatology. 2008;159(1):23–34.

3. Pan M et al. Urea in dermatology: a review. Dermatologic Therapy. 2012;25(1):22–31.

4. Kligman AM. Keratolytic effects of urea. Journal of the American Academy of Dermatology. 1988;18(4):779–785.

5. Jensen JM et al. Barrier function in dry skin. Experimental Dermatology. 2004;13(Suppl 4):22–30.

6. Gehring W. Hydrating effects of urea. Journal of Cosmetic Dermatology. 2004;3(2):88–93.

7. Rawlings AV, Harding CR. Moisturization mechanisms. Dermatologic Therapy. 2004;17(Suppl 1):43–48.

At Xtrimoist®, we go beyond surface hydration with barrier-focused skincare engineered to restore, strengthen, and protect sensitive and compromised skin from modern environmental stressors.

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